Hygiene is an unincorporated community with a U.S. Post Office in Boulder County, Colorado, United States. Application for the first Hygiene Post Office was made by Rev. Jacob Stoner Flory of the United Church of the Brethren on May 28, 1883 ZIP Code 80533. This community's name stems from a time when it had a sanatorium to work with tuberculosis patients.The prestigious Hygiene Home was developed by Jacob S. Flory. Articles of Incorporation were filed with the Boulder County Clerk as the Crystal Fountains, Hygienic Home, and White Sulphur Springs Company. A Warranty Deed was obtained for the property adjacent to the present Hygiene Elementary School on January 31, 1882. An advertisement in the "Longmont Ledger" April 13, 1883 announced that the Hygiene Home was open for the season. The Brethren Church is no longer in use as a church. The building is owned by the cemetery association. As of summer, 2013, it is in the process of restoration. The community association has held some of its meetings in the church building in 2013–2015. Hygiene has a US Post Office (80533), a church (Hygiene United Methodist Church), a school (Hygiene Elementary) and a cemetery. The Hygiene Community Association was formed in 2011 to preserve historical information and promote the community. "Hygiene Hay Days" was created as an autumn community festival by Hygiene business owners in 2012. In 2013 the festival was organized by a cooperative effort of business owners and the Hygiene Community Association. The festival was held again, larger, in 2014. The BNSF Railway has trackage on the south edge of Hygiene which is a branch line connecting Longmont and the Cemex cement plant at Lyons, Colorado.

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